National, State, and Local Area Vaccination Coverage Among Children Aged 19–35 Months — United States, 2012

The National Immunization Survey (NIS) is a random-digit-dialed telephone survey used to monitor vaccination coverage among U.S. children aged 19-35 months. This report describes national, state, and selected local area vaccination coverage estimates for children born during January 2009-May 2011, based on results from the 2012 NIS. Healthy People 2020* objectives set childhood vaccination targets of 90% for ≥1 doses of measles, mumps, and rubella vaccine (MMR); ≥3 doses of hepatitis B vaccine (HepB); ≥3 doses of poliovirus vaccine; ≥1 doses of varicella vaccine; ≥4 doses of diphtheria, tetanus, and pertussis vaccine (DTaP); ≥4 doses of pneumococcal conjugate vaccine (PCV); and the full series of Haemophilus influenzae type b vaccine (Hib). Vaccination coverage remained near or above the national Healthy People 2020 target for ≥1 doses of MMR (90.8%), ≥3 doses of poliovirus vaccine (92.8%), ≥3 doses of HepB (89.7%), and ≥1 doses of varicella vaccine (90.2%). Coverage increased from 68.6% in 2011 to 71.6% in 2012 for the birth dose of HepB.† Coverage was below the Healthy People 2020 target and either decreased or remained stable relative to 2011 for ≥4 doses of DTaP (82.5%), the full series of Hib (80.9%), and ≥4 doses of PCV (81.9%). Coverage also remained stable relative to 2011 and below the Healthy People 2020 targets of 85% and 80%, respectively, for ≥2 doses of hepatitis A vaccine (HepA) (53.0%), and rotavirus vaccine (68.6%). The percentage of children who had not received any vaccinations remained <1.0%. Although disparities in coverage were not observed for most racial/ethnic groups, children living in families with incomes below the federal poverty level had lower coverage than children living in families at or above the poverty level for ≥4 doses of DTaP (by 6.5 percentage points), the full Hib series (by 7.6 percentage points), ≥4 doses of PCV (by 8.6 percentage points), ≥2 doses of HepA (by 6.0 percentage points), and rotavirus vaccine (by 9.5 percentage points). Maintaining high coverage levels is important to maintain the current low burden of vaccine-preventable diseases in the United States and prevent their resurgence.

The National Immunization Survey (NIS) is a random-digitdialed telephone survey used to monitor vaccination coverage among U.S. children aged 19-35 months. This report describes national, state, and selected local area vaccination coverage estimates for children born during January 2009-May 2011, based on results from the 2012 NIS. Healthy People 2020* objectives set childhood vaccination targets of 90% for ≥1 doses of measles, mumps, and rubella vaccine (MMR); ≥3 doses of hepatitis B vaccine (HepB); ≥3 doses of poliovirus vaccine; ≥1 doses of varicella vaccine; ≥4 doses of diphtheria, tetanus, and pertussis vaccine (DTaP); ≥4 doses of pneumococcal conjugate vaccine (PCV); and the full series of Haemophilus influenzae type b vaccine (Hib). Vaccination coverage remained near or above the national Healthy People 2020 target for ≥1 doses of MMR (90.8%), ≥3 doses of poliovirus vaccine (92.8%), ≥3 doses of HepB (89.7%), and ≥1 doses of varicella vaccine (90.2%). Coverage increased from 68.6% in 2011 to 71.6% in 2012 for the birth dose of HepB. † Coverage was below the Healthy People 2020 target and either decreased or remained stable relative to 2011 for ≥4 doses of DTaP (82.5%), the full series of Hib (80.9%), and ≥4 doses of PCV (81.9%). Coverage also remained stable relative to 2011 and below the Healthy People 2020 targets of 85% and 80%, respectively, for ≥2 doses of hepatitis A vaccine (HepA) (53.0%), and rotavirus vaccine (68.6%). The percentage of children who had not received any vaccinations remained <1.0%. Although disparities in coverage were not observed for most racial/ethnic groups, children living in families with incomes below the federal poverty level had lower coverage than children living in families at or above the poverty level for ≥4 doses of DTaP (by 6.5 percentage points), the full Hib series (by 7.6 percentage points), ≥4 doses of PCV (by 8.6 percentage points), ≥2 doses of HepA (by 6.0 percentage points), and rotavirus vaccine (by 9.5 percentage points). Maintaining high coverage levels is important to maintain the current low burden of vaccine-preventable diseases in the United States and prevent their resurgence (1).
NIS uses a quarterly, random-digit-dialed sample of telephone numbers to reach households with children aged 19-35 months in the 50 states and selected local areas and territories, § followed by a mail survey sent to the children's vaccination providers to collect vaccination information. Data were weighted to represent the population of children aged 19-35 months, with adjustments for households with multiple telephone lines and mixed telephone use (landline and cellular), household nonresponse, and exclusion of households without telephone service. ¶ Beginning in 2011, NIS changed from sampling only landline telephones to a dual-frame sampling scheme, with interviews conducted via landline or cellular telephone. The response rate** for the 2012 NIS was 64.7% for the landline telephone sample (including the U.S. Virgin Islands) and 30.6% for the cellular telephone sample. Providers returned vaccination records for 67.6% of the 12,727 children with completed household interviews from the landline sample and 63.9% of the 13,009 children with completed household interviews from the cellular telephone sample, for a total of 16,916 children with provider-reported vaccination records included in this report. Of this total, 8,313 (49%) were from the cellular telephone sample, of whom 5,281 were from households with only cellular telephone service. Because the number of Hib † † and rotavirus vaccine § § doses required differs according to manufacturer, coverage estimates for these vaccines take into account the type of vaccine used. Logistic regression was used to examine differences among racial/ethnic groups, controlling for poverty status. Statistical analyses were conducted using t-tests based on weighted data and accounting for the complex survey design. A p-value of <0.05 was considered statistically significant.
In Coverage with the combined vaccine series (4:3:1:3*:3:1:4)*** was 68.4% in 2012, also similar to coverage in 2011. Children in families with incomes below the federal poverty level † † † had lower coverage than children in families at or above the poverty level for ≥3 and ≥4 doses of DTaP, primary and full series of Hib, ≥3 and ≥4 doses of PCV, ≥2 doses of HepA, rotavirus vaccine, and the combined vaccine series ( Table 2). Children were classified as below poverty if their total family income was less than the poverty threshold specified for the applicable family size and number of children aged <18 years. All others were classified as at or above poverty. Poverty thresholds reflect yearly changes in the Consumer Price Index. Thresholds and guidelines available at http://www.census.gov/hhes/www/poverty.html. § Children in the 2012 National Immunization Survey were born during January 2009-May 2011. ¶ Estimates are statistically significant at p<0.05. Children identified as non-Hispanic white were the reference group. ** Estimates are statistically significant at p<0.05. Children living at or above poverty were the reference group. †

Editorial Note
The results of the 2012 NIS indicate that vaccination coverage among children aged 19-35 months continues to be near or above the Healthy People 2020 target of 90% for MMR, poliovirus vaccine, HepB, and varicella vaccine. Although coverage estimates for many vaccines had small but statistically significant decreases compared with 2011, estimates are not directly comparable between years because NIS methods were changed. The number of interviews conducted via cellular telephone increased in 2012, such that approximately half of the 2012 NIS unweighted sample came from the cellular telephone sampling frame, compared with 11% of the 2011 unweighted sample. In 2012, an estimated 45% of U.S. children aged <18 years lived in households with cellular telephones only (3). The proportion of children aged 19-35 months living in households with only cellular telephone service estimated from the weighted 2012 NIS sample was 52.7%. Thus, the NIS sample now more closely resembles the U.S. population with respect to telephone service, and these 2012 vaccination  (2), coverage with the full series of Hib vaccine has reached levels in 2012 similar to those of DTaP and PCV, vaccines that also require a booster dose during the second year of life. Because the frequency of recommended well-child visits declines after age 12 months, fewer opportunities for catch-up doses with these vaccines exist when children fall behind schedule. CDC encourages the use of provider and system-based interventions aimed at encouraging adherence to well-child visits and facilitating delivery of vaccines at these visits. Examples include use of immunization information systems, provider assessment and feedback, provider reminders, standing orders, and provider education in conjunction with other interventions (4).
Coverage with HepA and rotavirus, the more recently recommended vaccines, also remained similar in 2012 compared with 2011, after several years of continued increase. Similar to Hib, DTaP, and PCV, the plateau in coverage for HepA might be attributable to fewer opportunities for catch-up doses, as the first dose of HepA is recommended during age 12-23 months. Children's vaccination status in NIS is determined up to age 19-35 months, so some children might have received their second dose, or might be due for the second dose, after the survey was conducted (the second dose is recommended 6-18 months after the first dose) (5). For rotavirus vaccine, the first dose should be given before age 14 weeks and 6 days because of insufficient evidence of safety in children aged >15 weeks, and the final dose should be given by age 8 months (5). These age restrictions might preclude infants from starting or completing the series. Health-care providers should make every effort to start and complete administration of the rotavirus vaccine series on time.
Although few differences in coverage by racial/ethnic group were observed after adjustment for poverty status, differences in coverage by poverty level remained for many vaccines. The Vaccines For Children program ¶ ¶ ¶ has been successful in removing differences in coverage between children living above and below the poverty level that once existed for vaccines such as MMR, polio, and HepB (6); however, coverage among children living below the poverty level still lags behind coverage of children living at or above the poverty level for newer vaccines (HepA and rotavirus) and vaccines that require 4 doses to complete the series.
Vaccination coverage continues to vary across states. Clusters of unvaccinated children leave communities vulnerable to outbreaks of disease. The continued occurrence of measles outbreaks among unvaccinated persons in the United States (7) underscores the importance of maintaining uniformly high coverage to prevent transmission of imported disease. Recent budget cuts to state and local health departments (8) as well as differences by state in factors such as population characteristics, immunization program activities, vaccination requirements for child-care centers, and vaccine financing policies might contribute to variations in vaccination coverage.
The findings in this report are subject to at least four limitations. First, the proportion of the NIS sampled by cellular telephone in 2012 was about half compared with only 11% in 2011 and zero in earlier years. Living in a household with only cellular telephone service is associated with poverty and other demographic factors that might be related to vaccination status (3). Second, underestimates of vaccination coverage might have resulted from the exclusive use of provider-reported vaccination histories because completeness of these records is unknown. Third, bias resulting from nonresponse and exclusion of households without telephone service might persist after weighting adjustments, although estimated bias from these sources for the 2011 NIS was low for selected vaccines examined, ranging from 0.3 (for MMR) to 1.5 (for ≥4 DTaP) percentage points (9). The potential for nonresponse bias was increased in 2012 because of the lower response rate for the cellular telephone sample. However, a comparison of vaccination coverage estimates from the NIS from July 2011 through June 2012 with those from the National Health Interview Survey during the same period yielded similar results, both overall and for children living in cellular-only households, despite largely different response rates between the two surveys (Assessment Branch, Immunization Services Division, National Center for Immunization and Respiratory Diseases, and Survey Planning and Special Surveys Branch, Division of Health Interview Statistics, National Center for Health Statistics, CDC; unpublished data; 2013). Finally, although national coverage estimates are precise, estimates for state and local areas should be interpreted with caution because of smaller sample sizes and wider confidence intervals.
High vaccination coverage among preschool-aged children has resulted in historically low levels of most vaccinepreventable diseases in the United States (1). The results of the 2012 NIS indicate that vaccination coverage among young children remained relatively stable and the proportion of children who do not receive any vaccinations has remained low. Slight decreases in coverage for some vaccines relative to 2011 cannot be immediately explained but could be attributable to a change in NIS methods. The 2012 results should be considered a baseline against which future trends in coverage can be evaluated. Careful monitoring of coverage levels overall and in subpopulations (e.g., racial/ethnic and geographic) is important to ensure that all children remain adequately protected. Parents and health-care providers should work to sustain high coverage and improve coverage for the more recently recommended vaccines and those that require booster doses after age 12 months. In addition to health system-based ¶ ¶ ¶ Additional information about the Vaccines for Children program is available at http://www.cdc.gov/vaccines/programs/vfc/default.htm.

What is already known on this topic?
Healthy People 2020 set childhood vaccination targets of 90% for ≥1 doses of measles, mumps, rubella vaccine (MMR); ≥3 doses of hepatitis B vaccine (HepB); ≥3 doses of poliovirus vaccine; ≥1 doses of varicella vaccine; ≥4 doses of diphtheria, tetanus, and pertussis vaccine; ≥4 doses of pneumococcal conjugate vaccine; and the full series of Haemophilus influenzae type b vaccine. The National Immunization Survey estimates coverage among U.S. children aged 19-35 months for these and other vaccines.
What is added by this report?
In 2012, childhood vaccination coverage remains near or above national target levels for ≥1 doses of MMR (90.8%), ≥3 doses of HepB (89.7%), ≥3 doses of poliovirus vaccine (92.8%), and ≥1 doses of varicella vaccine (90.2%); however, coverage varied by state and tended to be lower among children in families with incomes below the federal poverty level.
What are the implications for public health practice?
Sustaining current coverage levels and increasing coverage for those vaccines below national target levels is needed to maintain the low levels of vaccine-preventable diseases and prevent a resurgence of these diseases in the United States. Ensuring systems such as client reminder/recall and vaccination programs are in place in settings such as Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) clinics and child-care facilities can help support high vaccination coverage.
interventions previously described, national, state and local immunization programs should continue to partner with providers to implement the Guide to Community Preventive Services-recommended interventions aimed at increasing community demand for vaccination, such as client reminder/ recall and client or family incentives. Enhanced access to health services also is recommended, through reduced out-of-pocket costs, home visits, and vaccination programs in child-care centers, schools, and Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) settings**** (4). Health insurance reforms of the Affordable Care Act require health plans to cover recommended immunizations without cost to the enrollee when administered by an in-network provider (10). † † † †